pomegranate flower extract does not prevent cisplatin-induced nephrotoxicity in female rats
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چکیده
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منابع مشابه
Pomegranate Flower Extract does not Prevent Cisplatin-Induced Nephrotoxicity in Female Rats
BACKGROUND Nephrotoxicity is the major side-effect of cisplatin (CDDP), and it is reported to be gender-related. We evaluated the effects of pomegranate flower extract (PFE) as an antioxidant on CDDP-induced nephrotoxicity in female rats. METHODS Twenty-three adult female rats in four groups treated as following. Groups 1 and 2 received PFE at doses of 25 and 50 (mg/kg/day), respectively, for...
متن کاملnegative response of phytoestrogens of pomegranate flower extract against cisplatin‑induced nephrotoxicity in female rats
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متن کاملEffect of pomegranate flower extract on cisplatin-induced nephrotoxicity in rats
BACKGROUND Chemotherapy with cisplatin (CP) is accompanied with nephrotoxicity. OBJECTIVES In the current study, pomegranate flower extract (PFE) has been evaluated as an antioxidant agent against CP-induced-renal toxicity. MATERIALS AND METHODS Thirty two male Wistar rats were divided into five groups (6-8 in each group). The animals in groups 1 to 3 received PFE (25 mg/kg), PFE (50 mg/kg)...
متن کاملComment on: effect of pomegranate flower extract oncis platin-induced nephrotoxicity in rats
Implication for health policy/practice/research/medical education: Antioxidant supplements have generally beneficial effects, however, several factors such as the kind of the antioxidant and the dose should be considered to avoid the potential negative effects. Dear editor We read with respect the paper " effect of pomegranate flower extract on cisplatin-induced nephrotoxicity in rats " by Mota...
متن کاملEffect of Glutathione on Cisplatin-Induced Nephrotoxicity in Male and Female Rats
SUMMARY Cisplatin is a widely used anticancer agents that is effective against ovarian and other tumors. This drug is recognized as nephrotoxic in human and experimental animals. The effect of cisplatin-induced kidney injury was predominantly investigated in male animals. This study was designed to assess effects of cisplatin on male and female rat kidneys. We also investigated the effect of g...
متن کاملEffect of Simvastatin on Cisplatin-induced Nephrotoxicity in Male Rats
Statins have antioxidant and anti-inflammatory effects that are not directly related to their cholesterol-lowering activity. This study aimed to investigate the effect of simvastatin on the extent of tissue damage in cisplatin-induced nephrotoxicity. Simvastatin was orally given to rats in different doses (1, 2 and 4 mg/kg), 1 h prior to cisplatin injection (5 mg/kg, i.p.). All animals we...
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عنوان ژورنال:
international journal of preventive medicineجلد ۵، شماره ۱۲، صفحات ۱۶۲۱-۰
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